Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects

@article{Bhutta2001InteractionsOI,
  title={Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects},
  author={Adnan T. Bhutta and Cynthia R. Rovnaghi and Pippa M. Simpson and Jeffrey M. Gossett and Kanwaljeet J S Anand},
  journal={Physiology & Behavior},
  year={2001},
  volume={73},
  pages={51-58}
}
Neonatal rat pups exposed to repetitive acute pain show decreases in pain threshold and altered behavior during adulthood. A model using prolonged inflammatory pain in neonatal rats may have greater clinical relevance for investigating the long-term behavioral effects of neonatal pain in ex-preterm neonates. Neonatal rat pups were exposed to repeated formalin injections on postnatal (P) days 1-7 (P1-P7), with or without morphine pretreatment, and were compared with untreated controls… CONTINUE READING
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