Interactions of hyperthermia and drugs: treatments and probes.

  title={Interactions of hyperthermia and drugs: treatments and probes.},
  author={George M. Hahn and Gordon Li},
  journal={National Cancer Institute monograph},
At temperatures above 37 degrees C, the abilities of many, but not of all, anticancer drugs to kill cells increases substantially. The increased cytotoxic rate can vary smoothly with temperature (e.g., nitrosoureas or cis-platinum(II) diamminedichloride) or show a marked threshold near 43 degrees C (e.g., adriamycin or bleomycin). Clinically, the increased cell killing rate can be used in the combination of localized hyperthermia and systemic chemotherapy. Drugs can also be useful in the study… CONTINUE READING
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