Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo

@article{Berg1991InteractionsOH,
  title={Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo},
  author={Dr. K. J. Van den Berg and J. A. G. M. van Raaij and Peter C. Bragt and Wilfried R F Notten},
  journal={Archives of Toxicology},
  year={1991},
  volume={65},
  pages={15-19}
}
Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups were analyzed for direct interference with the T4 binding site of transthyretin using a competitive binding assay. Sixty per cent of the compounds were… CONTINUE READING

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