Interactions of glyceraldehyde-3-phosphate dehydrogenase with G- and F-actin predicted by Brownian dynamics.

@article{Ouporov2001InteractionsOG,
  title={Interactions of glyceraldehyde-3-phosphate dehydrogenase with G- and F-actin predicted by Brownian dynamics.},
  author={Igor V Ouporov and Harvey R. Knull and Stephen L Lowe and Kathryn A Thomasson},
  journal={Journal of molecular recognition : JMR},
  year={2001},
  volume={14 1},
  pages={29-41}
}
Brownian dynamics (BD) was used to simulate the binding of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to G- and F-actin. High-resolution three-dimensional models (X-ray and homology built) of the proteins were used in the simulations. The electrostatic potential about each protein was predicted by solving the linearized Poisson-Boltzmann equation for use in BD simulations. The BD simulations resulted in complexes of GAPDH with G- or F-actin involving positively charged surface patches on… CONTINUE READING