Interactions of fusidic acid and elongation factor G with lipid membranes.

@article{Muhonen2008InteractionsOF,
  title={Interactions of fusidic acid and elongation factor G with lipid membranes.},
  author={Jaana Muhonen and Jukka Vidgren and Anne Helle and Gebrenegus Yohannes and Tapani Viitala and Juha Holopainen and Susanne K Wiedmer},
  journal={Analytical biochemistry},
  year={2008},
  volume={374 1},
  pages={133-42}
}
Fusidic acid (FA) is a potent antibiotic and blocks the protein synthesis by binding to elongation factor G (EF-G) directly. Here we hypothesized that the antibiotic activity of FA would be potentiated by several orders of magnitude if both FA and EF-G would be residing in the lipid membranes and, hence, the probability of interaction would transform from three-dimensional to two-dimensional. Such detailed information could lead to more effective therapeutic interventions if they are understood… CONTINUE READING