Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection.

@article{CardonaGmez2001InteractionsOE,
  title={Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection.},
  author={Gloria Patricia Cardona-G{\'o}mez and Pablo Mendez and Lydia L. Doncarlos and I{\~n}igo Azcoitia and Luis Miguel Garcia-Segura},
  journal={Brain research. Brain research reviews},
  year={2001},
  volume={37 1-3},
  pages={320-34}
}
Data from epidemiological studies suggest that the decline in estrogen following menopause could increase the risk of neurodegenerative diseases. Furthermore, experimental studies on different animal models have shown that estrogen is neuroprotective. The mechanisms involved in the neuroprotective effects of estrogen are still unclear. Anti-oxidant effects, activation of different membrane-associated intracellular signaling pathways, and activation of classical nuclear estrogen receptors (ERs… CONTINUE READING