Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer.

@article{Magnusson2002InteractionsOD,
  title={Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer.},
  author={O. Magnusson and P. Frey},
  journal={Biochemistry},
  year={2002},
  volume={41 5},
  pages={
          1695-702
        }
}
  • O. Magnusson, P. Frey
  • Published 2002
  • Medicine, Chemistry
  • Biochemistry
  • 3',4'-Anhydroadenosylcobalamin (anAdoCbl) is an analogue of the adenosylcobalamin (AdoCbl) coenzyme (Magnusson, O.Th., and Frey, P. A. (2000) J. Am. Chem. Soc. 122, 8807-8813). This compound supports activity for diol dehydrase at 0.02% of that observed with AdoCbl. In a side reaction, however, anAdoCbl induces suicide inactivation by an electron-transfer mechanism. Homolytic cleavage of the Co-C bond of anAdoCbl at the active site of diol dehydrase was observed by spectrophotometric detection… CONTINUE READING
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