Interactions of cytosolic sulfotransferases with xenobiotics.

  title={Interactions of cytosolic sulfotransferases with xenobiotics.},
  author={Margaret O. James and Sriram Ambadapadi},
  journal={Drug metabolism reviews},
  volume={45 4},
Cytosolic sulfotransferases are a superfamily of enzymes that catalyze the transfer of the sulfonic group from 3'-phosphoadenosine-5'-phosphosulfate to hydroxy or amine groups in substrate molecules. The human cytosolic sulfotransferases that have been most studied, namely SULT1A1, SULT1A3, SULT1B1, SULT1E1 and SULT2A1, are expressed in different tissues of the body, including liver, intestine, adrenal, brain and skin. These sulfotransferases play important roles in the sulfonation of… CONTINUE READING
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