Interactions of cytokines and lipid mediators in acute and chronic inflammation.
@article{Hilger1995InteractionsOC, title={Interactions of cytokines and lipid mediators in acute and chronic inflammation.}, author={Ralf Axel Hilger and Manfred K{\"o}ller and J{\"o}rg Fr{\"a}nken and J. P. Rihoux and Wolfgang König}, journal={International archives of allergy and immunology}, year={1995}, volume={107 1-3}, pages={ 383-4 } }
Priming Cytokines Colony-stimulating factors Lipid mediators Atopy Correspondence to: Prof. Dr. med. W. König, Ruhr-Universität Bochum Medizinische Fakultät, Abt. für Med. Mikrobiologie und Immunologie, Universitätsstrasse 150, D–44780 Bochum (Germany) We analysed the effects of the growth factors granulo-cyte/macrophage-colony-stimulating factor (GM-CSF) and granulocyte-colony-stimulating factor (G-CSF), as well as the cytokines interleukin (IL)-3 and IL-8 on the generation of leukotriene (LT…
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4 References
Interleukin-3, interleukin-8, FMLP and C5a enhance the release of leukotrienes from neutrophils of patients with atopic dermatitis.
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- 1991
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