Interactions of chemicals and metal ions with proteins and role for immune responses.

@article{Martin2006InteractionsOC,
  title={Interactions of chemicals and metal ions with proteins and role for immune responses.},
  author={Stefan F Martin and Irmgard Merfort and Hermann-Josef Thierse},
  journal={Mini reviews in medicinal chemistry},
  year={2006},
  volume={6 3},
  pages={247-55}
}
Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease. 

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