Interactions of bisquaternary pyridine salts (H-Oximes) with cholinergic receptors

@article{KuhnenClausen1983InteractionsOB,
  title={Interactions of bisquaternary pyridine salts (H-Oximes) with cholinergic receptors},
  author={D. Kuhnen-Clausen and I. Hagedorn and Gerhard W. Gross and Hubert Bayer and Ferdinand Hucho},
  journal={Archives of Toxicology},
  year={1983},
  volume={54},
  pages={171-179}
}
Certain recently developed antidotes of the bispyridinium type, commonly called “H-oximes” (HGG 12, 21, 42, 52, 65, 70, 89, and HGG 90) have been investigated as to their effects on muscarinic and nicotinic acetylcholine receptors. These compounds clearly discriminate between these two types of receptors being more potent inhibitors of the muscarinic receptor with inhibitory constants in the micromole range. (The corresponding values for the nicotinic receptor are in the range of 0.1 mM… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Pharmacokinetics and toxicity of the oxime HGG 12 in dogs

  • Archives of Toxicology
  • 1985
VIEW 2 EXCERPTS
CITES BACKGROUND & RESULTS

References

Publications referenced by this paper.
SHOWING 1-10 OF 19 REFERENCES

Einfiihrung in die Neurochemie

F Hucho
  • Verlag Chemie, Weinheim Deerfield Beach Basel,
  • 1982

Reactivating potency of oximes and their effect on aging

Jong LPA, GZ Wolring
  • Protection against highly toxic substances
  • 1981

Reactivating potency of oximes and their effect on aging. In: Protection against highly toxic substances

LPA de Jong, GZ Wolring
  • 1981

Tierexperimentelle Untersuchungen mit potentiellen Antidoten zur Therapie einer Alkylphosphatvergiftung. In: Protection against highly toxic substances

H Oldiges, M Krigel
  • 1981
VIEW 1 EXCERPT

Entwicklung von hochwirksamen Gegenmitteln bei Vergiftungen mit toxischen Phosphors~iureestern

G Gross
  • Thesis, University of Freiburg i. Br.,
  • 1980
VIEW 2 EXCERPTS

Pyridinium salts as organophosphate antagonists.

  • Monographs in neural sciences
  • 1980
VIEW 2 EXCERPTS