Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B-miltefosine-loaded nanocochleates.

@article{Phm2013InteractionsOA,
  title={Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B-miltefosine-loaded nanocochleates.},
  author={Thu H{\`a} Phạm and Gillian Barratt and Jean Paul Michel and Philippe Marie Loiseau and Michĕle Saint-Pierre-Chazalet},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2013},
  volume={106},
  pages={
          224-33
        }
}
The emergence of strains of Leishmania resistant to existing drugs complicates the treatment of life-threatening visceral leishmaniasis. The development of new lipid formulation (nanocochleates), containing two active drugs: amphotericin B (AmB) and miltefosine (hexadecylphosphocholine, HePC), could increase effectiveness, decrease toxicity and reduce the risk of appearance of resistance. Nanocochleates are cigar-shaped structures of rolled negatively charged lipid bilayers bridged by calcium… CONTINUE READING

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