Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response.

@article{Kanchan2007InteractionsOA,
  title={Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response.},
  author={Vibhu Kanchan and Amulya Kumar Panda},
  journal={Biomaterials},
  year={2007},
  volume={28 35},
  pages={
          5344-57
        }
}
Size of the polymeric particulate antigen delivery system and its interactions with antigen-presenting cells (APCs) influence the immune response both qualitatively and quantitatively. In this paper, we report that antigen-loaded polymeric microparticles elicit antibody titers without being phagocytosed by macrophages; and size of the antigen-loaded particles modulates immune response from single-point immunization. Antibody titers varied significantly from single-point immunization with… CONTINUE READING
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