Interactions of anticancer drugs with usual and mismatch base pairs - density functional theory studies.

@article{Deepa2008InteractionsOA,
  title={Interactions of anticancer drugs with usual and mismatch base pairs - density functional theory studies.},
  author={Paul Deepa and P. Kolandaivel and Kittusamy Senthilkumar},
  journal={Biophysical chemistry},
  year={2008},
  volume={136 1},
  pages={50-8}
}
The antitumor activity of a drug is associated with its molecular properties as well as its interactions with target molecules. The molecular structures of usual, mismatch base pairs and their drug (Hydroxyurea and 5-Fluorouracil) interacting complexes were studied using density functional theory methods. The two and three-body interaction energies have… CONTINUE READING