Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes.

  title={Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes.},
  author={Katsumi Matsuzaki and C Horikiri},
  volume={38 13},
Interactions between amyloid beta-peptides (Abeta) and neuronal membranes have been postulated to play an important role in the neuropathology of Alzheimer's disease. To gain insight into the molecular details of this association, we investigated the interactions of Abeta (1-40) with ganglioside-containing membranes by circular dichroism (CD) and Fourier transform infrared-polarized attenuated total reflection (FTIR-PATR) spectroscopy. The CD study revealed that at physiological ionic strength… CONTINUE READING
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