Interactions of aminoglycoside antibiotics with negatively charged lipid layers. Biochemical and conformational studies.

@article{Brasseur1984InteractionsOA,
  title={Interactions of aminoglycoside antibiotics with negatively charged lipid layers. Biochemical and conformational studies.},
  author={R. Brasseur and Guy Laurent and Jean Marie Ruysschaert and Paul M Tulkens},
  journal={Biochemical pharmacology},
  year={1984},
  volume={33 4},
  pages={629-37}
}
Previous studies [Laurent et al., Biochem. Pharmac. 31, 3861 (1982)] have demonstrated that aminoglycoside antibiotics bind to negatively charged phospholipid bilayers and inhibit the activity of lysosomal phospholipases. This inhibition also occurs in vivo in animal and man. It is considered to be an early and significant step in the development of aminoglycoside-induced nephrotoxicity. The binding of 6 aminoglycosides in current clinical use (dibekacin, gentamicin, tobramycin, kanamycin A… CONTINUE READING

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