Interactions of alkali cations with glutamate transporters

@article{Holley2008InteractionsOA,
  title={Interactions of alkali cations with glutamate transporters},
  author={David C. Holley and Michael P. Kavanaugh},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2008},
  volume={364},
  pages={155 - 161}
}
The transport of glutamate is coupled to the co-transport of three Na+ ions and the countertransport of one K+ ion. In addition to this carrier-type exchange behaviour, glutamate transporters also behave as chloride channels. The chloride channel activity is strongly influenced by the cations that are involved in coupled flux, making glutamate transporters representative of the ambiguous interface between carriers and channels. In this paper, we review the interaction of alkali cations with… CONTINUE READING

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Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.

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