Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells

@article{Sun2017InteractionsOT,
  title={Interactions of TLR4 and PPAR$\gamma$, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells},
  author={Haijian Sun and Xuexue Zhu and Wei Lin and Yue-tao Zhou and Weiwei Cai and Liying Qiu},
  journal={Cellular Physiology and Biochemistry},
  year={2017},
  volume={42},
  pages={1227 - 1239}
}
Background /Aims: Accumulating evidence indicates that endothelial inflammation is one of the critical determinants in pathogenesis of atherosclerotic cardiovascular disease. Our previous studies had demonstrated that Vaccariae prevented high glucose or oxidative stress-triggered endothelial dysfunction in vitro. Very little is known about the potential effects of hypaphorine from Vaccariae seed on inflammatory response in endothelial cells. Methods: In the present study, we evaluated the anti… 

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