Interactions of RKIP with inflammatory signaling pathways.

  title={Interactions of RKIP with inflammatory signaling pathways.},
  author={Jinming Zhao and Sally E Wenzel},
  journal={Critical reviews in oncogenesis},
  volume={19 6},
The inflammatory response plays an important role in host defense and maintenance of homeostasis, while imbalances in these responses can also lead to pathologic disease processes. Emerging data show that RKIP interacts with multiple signaling molecules that may potentiate multiple functions during inflammatory processes. Here, we review the interaction of RKIP with both the MAPK and NF-κB pathways in relation to chronic inflammatory diseases. In these settings, it can both inhibit inflammatory… CONTINUE READING