Interactions of Phosphatase and Tensin Homologue (PTEN) Proteins with Phosphatidylinositol Phosphates: Insights from Molecular Dynamics Simulations of PTEN and Voltage Sensitive Phosphatase

@inproceedings{Kalli2014InteractionsOP,
  title={Interactions of Phosphatase and Tensin Homologue (PTEN)
Proteins with Phosphatidylinositol Phosphates: Insights from Molecular
Dynamics Simulations of PTEN and Voltage Sensitive Phosphatase},
  author={Antreas C. Kalli and Isabel Devaney and Mark S. P. Sansom},
  booktitle={Biochemistry},
  year={2014}
}
The phosphatase and tensin homologue (PTEN) and the Ciona intestinalis voltage sensitive phosphatase (Ci-VSP) are both phosphatidylinositol phosphate (PIP) phosphatases that contain a C2 domain. PTEN is a tumor suppressor protein that acts as a phosphatase on PIP3 in mammalian cell membranes. It contains two principal domains: a phosphatase domain (PD) and a C2 domain. Despite detailed structural and functional characterization, less is known about its mechanism of interaction with PIP… CONTINUE READING

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