Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF.

  title={Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF.},
  author={Tamar Golan and Arielle R Messer and Aya Amitai-Lange and Ze'ev Melamed and R. Andrew Ohana and Rachel E. Bell and Oxana Kapitansky and Galya Lerman and Shoshana Greenberger and Mehdi Khaled and Nira Amar and Jean Albrengues and Cedric Gaggioli and Pinchas Gonen and Yuval Tabach and David Sprinzak and Ruby Shalom-Feuerstein and Carmit Levy},
  journal={Molecular cell},
  volume={59 4},
The most critical stage in initiation of melanoma metastasis is the radial to vertical growth transition, yet the triggers of this transition remain elusive. We suggest that the microenvironment drives melanoma metastasis independently of mutation acquisition. Here we examined the changes in microenvironment that occur during melanoma radial growth. We show that direct contact of melanoma cells with the remote epidermal layer triggers vertical invasion via Notch signaling activation, the latter… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 13 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

Journal of experimental & clinical cancer research : CR • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 38 references

Modeling genomic

W. M. Lin, A. C. Baker, +7 authors C Gates
View 7 Excerpts
Highly Influenced

Melanoma development and progression: a conspiracy between tumor and host.

Differentiation; research in biological diversity • 2002
View 5 Excerpts
Highly Influenced

The many faces of Notch signaling in skin-derived cells.

Pigment cell research • 2007
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…