Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF.

@article{Golan2015InteractionsOM,
  title={Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF.},
  author={Tamar Golan and Arielle R Messer and Aya Amitai-Lange and Ze'ev Melamed and R. Andrew Ohana and Rachel E. Bell and Oxana Kapitansky and Galya Lerman and Shoshana Greenberger and Mehdi Khaled and Nira Amar and Jean Albrengues and Cedric Gaggioli and Pinchas Gonen and Yuval Tabach and David Sprinzak and Ruby Shalom-Feuerstein and Carmit Levy},
  journal={Molecular cell},
  year={2015},
  volume={59 4},
  pages={664-76}
}
The most critical stage in initiation of melanoma metastasis is the radial to vertical growth transition, yet the triggers of this transition remain elusive. We suggest that the microenvironment drives melanoma metastasis independently of mutation acquisition. Here we examined the changes in microenvironment that occur during melanoma radial growth. We show that direct contact of melanoma cells with the remote epidermal layer triggers vertical invasion via Notch signaling activation, the latter… CONTINUE READING
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