Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles.

@article{SchmittUlms2009InteractionsOM,
  title={Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles.},
  author={Gerold Schmitt-Ulms and Dorthe Matenia and Gerard Drewes and E. -M. Mandelkow},
  journal={Cell motility and the cytoskeleton},
  year={2009},
  volume={66 8},
  pages={661-72}
}
MARK [microtubule-associated proteins (MAPs)/microtubule affinity regulating kinase]/Par-1 (partition defective) phosphorylate MAPs tau, MAP2 and MAP4 at KXGS motifs and thereby regulate microtubule dynamics and transport processes in cells [Drewes et al., Cell1997;89:297-308]. We report here that MARK copurifies with clathrin-coated vesicles (CCVs) via interaction with the adaptor complex AP-2. The adaptin binding site on MARK includes the regulatory loop of its catalytic domain… CONTINUE READING

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