Interactions of Hyperthermia and Chemotherapy in Animals

  title={Interactions of Hyperthermia and Chemotherapy in Animals},
  author={Jane B. Marmor},
  journal={Cancer research},
  volume={39 6 Pt 2},
In tissue culture, the cytotoxicity of a number of commonly used chemotherapeutic drugs is greatly enhanced at elevated temperatures. However, pharmacokinetics, drug concentra tions, oxygen tension, and pH in tumors in animals can all vary widely from those in cell cultures. In addition, tissue culture studies do not give vital information on the effect of combina tions of drugs and hyperthermia on normal tissues or metas tases. Available studies of drugs and hyperthermia in animals are… CONTINUE READING


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