Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.

  title={Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.},
  author={Karl M{\"u}nger and Martin Scheffner and Jon M. Huibregtse and Peter M Howley},
  journal={Cancer surveys},
The HPVs associated with anogenital cancers encode two oncoproteins, E6 and E7. Both E6 and E7 can form specific complexes with tumour suppressor gene products. The E7 protein binds to the retinoblastoma tumour suppressor gene product pRB, with a preference for the underphosphorylated, "active" form of pRB. The E7 proteins derived from the "high risk" HPVs bind to pRB with a higher affinity than the E7 proteins from the "low risk" HPVs. The "high risk" HPV E6 proteins can associate with the p53… CONTINUE READING
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