Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition.

  title={Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition.},
  author={Sen Shi and Swayam Prakash Srivastava and Megumi Kanasaki and Jianhua He and Munehiro Kitada and Takako Nagai and Kyoko Nitta and Susumu Takagi and Keizo Kanasaki and Daisuke Koya},
  journal={Kidney international},
  volume={88 3},
Integrin β1 and dipeptidyl peptidase (DPP)-4 play roles in endothelial cell biology. Vascular endothelial growth factor (VEGF)-A inhibits endothelial-to-mesenchymal transition (EndMT) through VEGF-R2, but through VEGF-R1 promotes EndMT by reducing the bioavailability of VEGF-A. Here we tested whether DPP-4-integrin β1 interactions have a role in EndMT in the renal fibrosis of diabetic nephropathy. In streptozotocin-induced fibrotic kidneys in diabetic CD-1 mice, levels of endothelial DPP-4… CONTINUE READING
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