Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells.

@article{Bhat1997InteractionsOC,
  title={Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells.},
  author={Aarti Hejmadi Bhat and Kathryn S. Kolibaba and Tomohiro Oda and Sayuri Ohno-Jones and Chelcie Heaney and Brian J. Druker},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 26},
  pages={16170-5}
}
The Philadelphia chromosome, detected in virtually all cases of chronic myelogenous leukemia (CML), is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR-encoded sequences upstream of exon 2 of c-ABL. The BCR-ABL fusion creates a gene whose protein product, p210BCR-ABL, has been implicated as the cause of the disease. Although ABL kinase activity has been shown to be required for the transforming abilities of BCR-ABL and numerous substrates of the BCR-ABL tyrosine… CONTINUE READING

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