Interactions of C12 surfactants with the skin: changes in enzymes and visible and histological features of rat skin treated with sodium lauryl sulphate.


Rat skin was treated with 35 mM-sodium lauryl sulphate (SLS) and samples were taken after one, three or five treatments, or 24 hr after the fifth treatment for measurement of enzyme release and epidermal enzyme levels. Release of acid phosphatase (AP) and lactate dehydrogenase (LDH) was significantly higher than in controls after five treatments with SLS… (More)


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