Interactions of BCNU, low pH, glucose and hyperthermia in cultured RIF cells.

@article{Neilan1988InteractionsOB,
  title={Interactions of BCNU, low pH, glucose and hyperthermia in cultured RIF cells.},
  author={Barbara A. Neilan and Tim Jenkins and Kurt J. Henle and A. J. Moss and William A. Nagle},
  journal={Cancer letters},
  year={1988},
  volume={39 3},
  pages={
          275-80
        }
}
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Combined effect of pH and sodium cyanate on the inhibition of tumor cell proliferation and metabolism by BCNU and hyperthermia
TLDR
The data confirmed that the inhibitory effect of sodium cyanate on cell proliferation can be enhanced by a low pH but did not provide evidence for synergistic effects in combination with BCNU or hyperthermia.
Effect of hypertonic glucose in thermotolerant rat BT4An gliomas treated with combined hyperthermia and BCNU in vivo.
  • B. Schem, O. Mella, S. Roszinski, O. Dahl
  • Medicine, Biology
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 1996
TLDR
Glucose administered before treatment of thermotolerant tumours did not change the growth rate of tumours treated with hyperthermia, BCNU, or thermochemotherapy with a low or high dose BCnU, in contrast to previous results, where glucose enhanced thermochemosensitivity of non-thermotolerants tumours.

References

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TLDR
It is shown that this dependence is greatly enhanced at 43 degrees and the cell-killing ability of four drugs in the pH range of 6.5 to 8.5 is examined, which may have some relevance in designing thermo-chemotherapeutic treatment protocols.
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TLDR
The results indicate that hyperglycemia induced by intraperitoneal glucose injection is effective in lowering the tumor pH of the murine RIF-1 tumor.
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TLDR
The addition of D-glucose, D-galactose, or D-mannose to culture medium increased survival of heated Chinese hamster ovary cells in a concentration- and time-dependent manner and may be related to the intracellular accumulation of free galactose and/or its metabolites.
Cytotoxicity of hyperthermia combined with bleomycin or cis-platinum in cultured RIF cells: modification by thermotolerance and by polyhydroxy compounds.
The effect of thermotolerance and of polyhydroxy compounds on the cytotoxicity of bleomycin and cis-platinum was studied in cultured RIF tumor cells. Cell survival in response to drug-heat treatments…
TEMPERATURE RANGE AND SELECTIVE SENSITIVITY OF TUMORS TO HYPERTHERMIA: A CRITICAL REVIEW
TLDR
It is apparent that, at temperatures above 44OC, the time difference required to damage normal compared to malignant tissue becomes too short for practical purposes, and the prolonged heating times required for tumor destruction likewise make such temperatures unsuitable for therapy purposes.