Interactions of Aldosterone Antagonist Diuretics with Human Serum Proteins

  title={Interactions of Aldosterone Antagonist Diuretics with Human Serum Proteins},
  author={Norito Takamura and Toru Maruyama and Shamim Ahmed and Ayaka Suenaga and Masaki Otagiri},
  journal={Pharmaceutical Research},
AbstractPurpose. The purpose of this study was to investigate the binding mechanism of aldosterone antagonist diuretics with human serum proteins, human serum albumin (HSA) and α1-acid glycoprotein (AGP), as well as to identify the binding sites of the drugs on these proteins. Methods. Binding activities of spironolactone (SP) and its pharmacologically active metabolite canrenone (CR) to serum and serum protein were examined by ultrafiltration and spectroscopic techniques. The data for the… Expand
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  • D. Sica
  • Medicine
  • Heart Failure Reviews
  • 2005
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