Interactions between tumor necrosis factor-alpha, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat.

@article{Bernardini1990InteractionsBT,
  title={Interactions between tumor necrosis factor-alpha, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat.},
  author={Renato Bernardini and Themis Kamilaris and Aldo E Calogero and Elizabeth Ourania Johnson and Marco A. Tequitlalpa G{\'o}mez and Philip W. Gold and George P. Chrousos},
  journal={Endocrinology},
  year={1990},
  volume={126 6},
  pages={2876-81}
}
We studied the effects of tumor necrosis factor-alpha (TNF alpha), a macrophage-derived pleiotropic cytokine produced during the inflammatory/immune response, on the function of the hypothalamic-pituitary-adrenal (HPA) axis of the rat. Intravenous injections of TNF alpha stimulated plasma ACTH and corticosterone secretion in a dose-dependent fashion. This effect was inhibited by a rat CRH antiserum that was administered to the rats 1 h before the TNF alpha injections. This suggested that CRH is… CONTINUE READING

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