Interactions between transient and sustained neural signals support the generation and regulation of anxious emotion.
@article{Somerville2013InteractionsBT, title={Interactions between transient and sustained neural signals support the generation and regulation of anxious emotion.}, author={Leah H. Somerville and Dylan D. Wagner and Gagan S. Wig and Joseph M. Moran and Paul J. Whalen and William M. Kelley}, journal={Cerebral cortex}, year={2013}, volume={23 1}, pages={ 49-60 } }
Anxious emotion can manifest on brief (threat response) and/or persistent (chronic apprehension and arousal) timescales, and prior work has suggested that these signals are supported by separable neural circuitries. This fMRI study utilized a mixed block-event-related emotional provocation paradigm in 55 healthy participants to simultaneously measure brief and persistent anxious emotional responses, testing the specificity of, and interactions between, these potentially distinct systems…
161 Citations
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- 2015
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- 2020
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It is demonstrated that amygdala responses to emotional movies spill over to subsequent processing of threat information in a valence-specific manner: negative movies enhance later amygdala activation whereas positive movies attenuate it, suggesting the importance of past experience in shaping future affective reactivity.
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Mechanistic studies demonstrate that both regions can control the expression of fear and anxiety during sustained exposure to diffuse threat and compel a reconsideration of the central extended amygdala's contributions toFear and anxiety and its role in neuropsychiatric disease.
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