Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.

@article{Bezsonova2008InteractionsBT,
  title={Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.},
  author={Irina Bezsonova and M. Christine Bruce and Silke Wiesner and Hong Li Lin and Daniela Rotin and Julie Deborah Forman-Kay},
  journal={Biochemistry},
  year={2008},
  volume={47 34},
  pages={8937-49}
}
CIN85 is an adaptor protein linking the ubiquitin ligase Cbl and clathrin-binding proteins in clathrin-mediated receptor endocytosis. The SH3 domains of CIN85 bind to a proline-rich region of Cbl. Here we show that all three SH3 domains of CIN85 bind to ubiquitin. We also present a data-based structural model of the CIN85 SH3-C domain in complex with ubiquitin. In this complex, ubiquitin binds to the canonical interaction surface of the SH3 domain for proline-rich ligands and mimics the PPII… CONTINUE READING

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