Interactions between the host innate immune system and microbes in inflammatory bowel disease.

@article{Abraham2011InteractionsBT,
  title={Interactions between the host innate immune system and microbes in inflammatory bowel disease.},
  author={Clara Abraham and Ruslan Medzhitov},
  journal={Gastroenterology},
  year={2011},
  volume={140 6},
  pages={1729-37}
}
The intestinal immune system defends against pathogens and entry of excessive intestinal microbes; simultaneously, a state of immune tolerance to resident intestinal microbes must be maintained. Perturbation of this balance is associated with intestinal inflammation in various mouse models and is thought to predispose humans to inflammatory bowel disease (IBD). The innate immune system senses microbes; dendritic cells, macrophages, and epithelial cells produce an initial, rapid response. The… CONTINUE READING
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