Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions.

Abstract

The double-stranded (ds) RNA binding proteins, TRBP and PACT bind the interferon-induced protein kinase PKR and dsRNA. TRBP inhibits, whereas PACT activates PKR. They have two dsRNA binding domains (dsRBDs) and a C-terminal domain that does not bind RNA. All three domains show a strong homology between the two proteins. Interaction assays by in vitro… (More)

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Cite this paper

@article{Laraki2008InteractionsBT, title={Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions.}, author={Ghislaine Laraki and Guerline Clerzius and A{\"i}cha Daher and Carlos E Melendez-Pe{\~n}a and S. Daniels and Anne Gatignol}, journal={RNA biology}, year={2008}, volume={5 2}, pages={92-103} }