Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias.

@article{Mann2004InteractionsBT,
  title={Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias.},
  author={Henning H. Mann and Suat Ozbek and J{\"u}rgen Engel and Mats Paulsson and Raimund Wagener},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 24},
  pages={
          25294-8
        }
}
The cartilage oligomeric matrix protein (COMP) and matrilins are abundant non-collagenous proteins in the cartilage extracellular matrix. In the presence of calcium, COMP and matrilin-1 elute together in the gel filtration of cartilage extracts and can be co-immunoprecipitated. In a screen for ligands of matrilin-1, -3, and -4 using an ELISA-style binding assay, COMP was identified as a prominent binding partner for all three, indicating a conservation of the COMP interaction among matrilins… CONTINUE READING
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