Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission.

@article{Mikics2009InteractionsBT,
  title={Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission.},
  author={{\'E}va Mikics and Judit Vas and Man{\'o} Aliczki and Jozsef Halasz and J{\'o}zsef Haller},
  journal={Behavioural pharmacology},
  year={2009},
  volume={20 3},
  pages={
          265-72
        }
}
  • Éva Mikics, Judit Vas, +2 authors József Haller
  • Published in Behavioural pharmacology 2009
  • Psychology, Medicine
  • Neuroanatomical findings revealed that CB1 cannabinoid and 5-HT3 receptors are coexpressed by a subtype of gamma-aminobutyric acid (GABA)ergic interneurons in the prefrontal cortex, hippocampus, and basolateral amygdala, three brain regions that are crucial for the control of anxiety. In these regions, serotonergic inputs increase GABA release through 5-HT3 receptors, the phenomenon being retrogradely controlled by cannabinoid neurotransmission. This suggests a functional interaction between 5… CONTINUE READING

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