Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.

@article{Milasta2006InteractionsBT,
  title={Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.},
  author={Sandra Milasta and John D. Pediani and Shirley Appelbe and Steven A Trim and Michael J Wyatt and Peter Cox and Mark D Fidock and Graeme Milligan},
  journal={Molecular pharmacology},
  year={2006},
  volume={69 2},
  pages={479-91}
}
When expressed via an inducible promoter in human embryonic kidney 293 cells, the rat Mas-related gene D (rMrgD) receptor responded to beta-alanine but not L-alanine by elevating intracellular [Ca(2+)], stimulating phosphorylation of the mitogenactivated protein kinases known as extracellular signal-regulated kinase (ERK) 1 and ERK2 and translocating from the plasma membrane to punctate intracellular vesicles. By contrast, the related rat Mas-related gene E (rMrgE) receptor did not respond to… CONTINUE READING