Interactions between tenocytes and monosodium urate monohydrate crystals: implications for tendon involvement in gout.

@article{Chhana2014InteractionsBT,
  title={Interactions between tenocytes and monosodium urate monohydrate crystals: implications for tendon involvement in gout.},
  author={Ashika Chhana and Karen E. Callon and Michael S Dray and Bregina Pool and Dorit Naot and Greg D Gamble and Brendan Coleman and Geraldine M. McCarthy and Fiona Marion McQueen and Jillian Cornish and Nicola D Dalbeth},
  journal={Annals of the rheumatic diseases},
  year={2014},
  volume={73 9},
  pages={1737-41}
}
OBJECTIVES Advanced imaging studies have demonstrated that urate deposition in periarticular structures, such as tendons, is common in gout. The aim of this study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on tenocyte viability and function. METHODS The histological appearance of tendons in joints affected by advanced gout was examined using light microscopy. In vitro, colorimetric assays and flow cytometry were used to assess cell viability in primary rat… CONTINUE READING