Interactions between subunits of Drosophila Mediator and activator proteins.

  title={Interactions between subunits of Drosophila Mediator and activator proteins.},
  author={Young-Joon Kim and John T Lis},
  journal={Trends in biochemical sciences},
  volume={30 5},
Mediator was first identified because of its activity in activator-stimulated transcription in vivo and in vitro. Later, biochemical fractionation led to the co-purification of the multi-subunit Mediator complex and RNA polymerase II (pol II). Results of these studies suggested a model whereby transcription-activator proteins, which bind to specific gene regulatory sequences, recruit both Mediator and pol II as a holoenzyme in a one-step mechanism. More recent studies of Drosophila Mediator and… CONTINUE READING

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