Interactions between somatic cells and germ cells throughout mammalian oogenesis.

  title={Interactions between somatic cells and germ cells throughout mammalian oogenesis.},
  author={Roberto Buccione and Allen C. Schroeder and John J. Eppig},
  journal={Biology of reproduction},
  volume={43 4},
Oocytes and their companion somatic cells maintain a close association throughout oogenesis and this association is essential for normal oocyte and follicular development. This review summarizes current concepts of the role of the somatic cells in the regulation of mammalian oocyte growth, the maintenance of meiotic arrest, the induction of oocyte maturation, and the acquisition of full embryonic developmental competence during oocyte maturation in vitro. Gap junctions appear to mediate these… 
Molecular control of oogenesis.
Chapter 3 Interaction of oocyte and somatic cells
This chapter aims to review the current state of knowledge of the cell–cell interactions and communication which occur between oocytes and somatic cells throughout their development and which act as a vehicle for oocyte metabolism and which underpin the processes of oocyte growth and maturation.
Influence of granulosa cells and of different somatic cell types on mammalian oocyte development in vitro.
The production of paracrine factors by granulosa cells has been suggested by the findings that these cells express the production of the Steel locus, the Steel factor (SLF) or kit ligand (KL), and that this factor promotes oocyte growth in vitro when used at high concentrations.
Oocyte-granulosa cell interactions during mouse follicular development: regulation of kit ligand expression and its role in oocyte growth
Elucidation of the molecular mechanisms that promote the development of healthy oocytes with good developmental competence has potential applications for improving fertility and for in vitro growth systems for oocytes from domestic animals and humans.
Oocyte control of ovarian follicular development and function in mammals.
  • J. Eppig
  • Biology, Medicine
  • 2001
The existence of an oocyte-granulosa cell regulatory loop, essential for normal follicular differentiation as well as for the production of a oocyte competent to undergo fertilization and embryogenesis, is proposed.
The molecular basis of oocyte growth and development
In vitro development of growing oocytes from fetal mouse oocytes: stage-specific regulation by stem cell factor and granulosa cells.
The preantral/antral transition point is indicated as a critical stage of oocyte development requiring the coordinated differentiation of the oocyte with granulosa cells and the maintenance of adequate communication between these two cell types to assure the correct oocyte meiotic maturation.
Oocyte growth in vitro: potential model for studies of oocyte–granulosa cell interactions
  • Y. Hirao
  • Biology
    Reproductive medicine and biology
  • 2012
In vitro culture of growing oocytes in terms of oocyte–granulosa cell interactions is discussed, finding some of the oocyte-mediated regulations have been confirmed in vitro, providing evidence of the usefulness of culture systems as a strong tool for such studies.
An oocentric view of folliculogenesis and embryogenesis.
Granulosa cell-oocyte interactions.


Effect of follicle cells on the maturation and developmental competence of ovine oocytes matured outside the follicle
The results demonstrate further that the nonstatic system provides a simple but reliable method of producing large numbers of fully matured oocytes for both research and clinical purposes.
Selective effect of gonadotrophins on cell coupling, nuclear maturation and protein synthesis in mammalian oocytes.
It is concluded that nuclear maturation is not dependent upon the disruption of cell contact between the oocyte and the surrounding follicle cells, and Membrane vesiculation and lysosomal change in the transzonal processes are early structural changes associated with the suppression of intercellular coupling in oocytes.
Follicle cell regulation of mammalian oocyte growth.
It was concluded that gap-junction-mediated nutrition of ovarian mouse oocytes exerted by somatic cells is necessary but not sufficient to maintain oocyte growth.
Meiotic resumption and gap junction modulation in the cultured rat cumulus-oocyte complex.
The results do support the earlier suggestion that gap junction loss within the cumulus oophorus is instrumental in isolating the oocyte from the regulatory influence of its underlying membrana granulosa cells during meiotic maturation in the intact preovulatory follicle.
Relationship between growth and meiotic maturation of the mouse oocyte.
An inhibitory influence of granulosa cells and follicular fluid upon porcine oocyte meiosis in vitro.
It is concluded that the granulosa cells are responsible for the maintenance of the oocytes in the dictyate stage within the follicle, and appear to exert their inhibitory influence upon meiosis by secretion of a chemical message into follicular fluid.