Interactions between selenium and methylmercury in rat brain.

@article{Prohaska1977InteractionsBS,
  title={Interactions between selenium and methylmercury in rat brain.},
  author={Joseph R. Prohaska and Howard E. Ganther},
  journal={Chemico-biological interactions},
  year={1977},
  volume={16 2},
  pages={155-67}
}
The interaction of selenium with methylmercury was investigated in brain of animals labeled with 75SeO2-3 and CH3203Hg+. Brains were fractionated into subcellular components and the cytosol was further fractionated by chromatography on Sephadex G-150 and G-200. The main result of these studies was evidence suggesting a shift of 75Se from the cytosol to the mitochondrial fraction in brain when CH3Hg+ was given. Concurrent equmolar (10 micronmoles/kg) selenite injections increased the uptake of… CONTINUE READING

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