Interactions between secretin and acetylcholine in the regulation of fluid secretion by isolated rat pancreatic ducts.

@article{Evans1996InteractionsBS,
  title={Interactions between secretin and acetylcholine in the regulation of fluid secretion by isolated rat pancreatic ducts.},
  author={R. Evans and N. Ashton and A. Elliott and R. Green and B. Argent},
  journal={The Journal of Physiology},
  year={1996},
  volume={496}
}
1. Interlobular ducts were isolated from the rat pancreas and maintained in short‐term tissue culture. Fluid secretion from these isolated ducts was measured using micropuncture techniques, intracellular calcium concentration ([Ca2+]i) by fura‐2 microspectrofluorimetry, and cyclic AMP by radioimmunoassay. 2. Applying secretin and ACh simultaneously to ducts caused either a stimulation or an inhibition of fluid secretion depending on the doses employed. 3. The inhibitory effect of secretin and… Expand
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