Interactions between rivaroxaban and antiphospholipid antibodies in thrombotic antiphospholipid syndrome.

@article{Arachchillage2015InteractionsBR,
  title={Interactions between rivaroxaban and antiphospholipid antibodies in thrombotic antiphospholipid syndrome.},
  author={Deepa Ranjani Jayakody Arachchillage and Ian Mackie and Maria Efthymiou and David Alan Isenberg and Samuel J. Machin and Hannah Cohen},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2015},
  volume={13 7},
  pages={1264-73}
}
INTRODUCTION Rivaroxaban can affect lupus anticoagulant (LA) testing and antiphospholipid antibodies (aPL) may interfere with the anticoagulant action of rivaroxaban. AIMS To establish the influence of rivaroxaban on LA detection and of aPL on the anticoagulant action of rivaroxaban. METHODS Rivaroxaban and 52 IgG preparations (20 LA+ve, 12 LA-ve thrombotic antiphospholipid syndrome [APS] patients, and 20 normal controls [NC]) were spiked into pooled normal plasma (PNP) for relevant studies… CONTINUE READING
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