Interactions between renin angiotensin system and advanced glycation in the kidney.

  title={Interactions between renin angiotensin system and advanced glycation in the kidney.},
  author={Merlin C Thomas and Christos Tikellis and Wendy M Burns and Katarzyna M Bialkowski and Z. -Y. Cao and Melinda T. Coughlan and Karen Jandeleit-Dahm and Mark Emmanuel Cooper and Josephine M Forbes},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={16 10},
Although hemodynamic and metabolic factors are individually implicated in the development of diabetic nephropathy, their interaction has not been defined clearly. In this study, the effects of angiotensin II (Ang II) and advanced glycation end products (AGE) both individually on each other are explored and compared. In the first study arm, Sprague-Dawley rats received a continuous infusion of AGE-modified rat serum albumin (RSA) or unmodified RSA for 4 wk with or without the angiotensin… CONTINUE READING
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