Interactions between progesterone receptor isoforms in myometrial cells in human labour.

@article{Pieber2001InteractionsBP,
  title={Interactions between progesterone receptor isoforms in myometrial cells in human labour.},
  author={Doris Pieber and Victoria Allport and Frank A Hills and M. Johnson and Phillip R. Bennett},
  journal={Molecular human reproduction},
  year={2001},
  volume={7 9},
  pages={875-9}
}
Progesterone acts to maintain uterine quiescence during pregnancy. In contrast to many other species, no decrease in maternal serum levels of progesterone can be observed in humans before the onset of labour. Therefore, a 'functional' progesterone withdrawal in association with labour has been proposed. In humans the progesterone receptor (PR) exists in two isoforms, PR-A and PR-B. While PR-B generally mediates the effects of progesterone upon gene transcription, the role of PR-A during… CONTINUE READING