Interactions between pesticide genes: model and experiment.

@article{Raymond1989InteractionsBP,
  title={Interactions between pesticide genes: model and experiment.},
  author={Michel Raymond and David G. Heckel and Jeffrey G Scott},
  journal={Genetics},
  year={1989},
  volume={123 3},
  pages={543-51}
}
In response to years of intense selection pressure by organophosphate insecticides, several different insecticide resistance mechanisms have evolved in natural populations of the mosquito Culex pipiens. We examined interactions between two of the most important mechanisms using a four-compartment model of insecticide pharmacokinetics. The joint effect of different mechanisms of resistance can be expressed in terms of epistasis at the physiological level in this model. The type of epistasis… CONTINUE READING

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