Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine

@article{Spignoli1987InteractionsBO,
  title={Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine},
  author={Giacomo Spignoli and Giancarlo Pepeu},
  journal={Pharmacology Biochemistry and Behavior},
  year={1987},
  volume={27},
  pages={491-495}
}
The effect of cognition-enhancing agents oxiracetam and aniracetam on scopolamine-induced amnesia and brain acetylcholine decrease was investigated in the rat. Acetylcholine levels were measured by means of a gas-chromatographic method. Scopolamine (0.63 mg/kg IP 60 min before training) prevented the acquisition of a passive avoidance conditioned response ("step through": retest 30 min after training) and brought about a 64, 56 and 42% decrease in acetylcholine level in the cortex, hippocampus… Expand
A decrease in brain catecholamines prevents oxiracetam antagonism of the effects of scopolamine on memory and brain acetylcholine.
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The hypothesis that an interaction between monoaminergic and cholinergic neurotransmitter systems may be involved in the actions of nootropic drugs on cognitive functions is supported, and oxiracetam was unable to prevent both amnesia and the decrease in brain ACh levels caused by scopolamine. Expand
Effect of pyroglutamic acid stereoisomers on ECS and scopolamine-induced memory disruption and brain acetylcholine levels in the rat.
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Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine
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The results indicate that alpha-GPC, when administered orally, reverses the amnesia caused by scopolamine in passive avoidance and is able to increase the amount of ACh released by rat hippocampus slices following potassium stimulation. Expand
Oxiracetam antagonizes the disruptive effects of scopolamine on memory in the radial maze
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The present results suggest that oxiracetam selectively restores cholinergic mechanisms which are involved in learning and memory in overtrained rats. Expand
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Reversal by nefiracetam of a nicotinic as well as a muscarinic cholinergic antagonist indicates that the drug may affect deficits specific to AD. Expand
Reversal effect of DM-9384 on scopolamine-induced acetylcholine depletion in certain regions of the mouse brain
  • E. Abe
  • Chemistry, Medicine
  • Psychopharmacology
  • 2005
TLDR
The results obtained indicate that the protective action of DM-9384 against scopolamine-induced amnesia is due to its ability to reverse the ACh depletion. Expand
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Treatment with Oxiracetam or Choline Restores Cholinergic Biochemical and Pharmacological Activities in Striata of Decorticated Rats
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The frontally decorticated rat could constitute a useful model for studying means to restore the deficit in striatal cholinergic neurotransmission and it is suggested that choline chloride acts directly simply by being the precursor for ACh, whereas oxiracetam may act indirectly, possibly by increasing the availability of Choline chloride for A Ch synthesis. Expand
Effects of D-cycloserine and Aniracetam on Spatial Learning in Rats with Entorhinal Cortex Lesions
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