Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines.

@article{Fisher2011InteractionsBM,
  title={Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines.},
  author={Janet L. Fisher},
  journal={European journal of pharmacology},
  year={2011},
  volume={654 2},
  pages={160-5}
}
Many patients with refractory epilepsy are treated with polytherapy, and nearly 15% of epilepsy patients receive two or more anti-convulsant agents. The anti-convulsant stiripentol is used as an add-on treatment for the childhood epilepsy syndrome known as severe myoclonic epilepsy in infancy (Dravet syndrome). Stiripentol has multiple mechanisms of action, both enhancing GABA(A) receptors and reducing activity of metabolic enzymes that break down other drugs. Stiripentol is typically co… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 34 references

160–165 comparison and calculation of in vivo inhibition

J. L. Fisher
European Journal of Pharmacology • 2011

Extrasynaptic GABAA receptors: form, pharmacology, and function.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 2 Excerpts

Rational polytherapy

C. Giraud, J.-M. Treluyer, +4 authors A. Tran
Epilepsia • 2009

Inherited neuronal ion channelopathies: new windows on complex neurological diseases.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 1 Excerpt

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