Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin.

@article{Ridgway2000InteractionsBM,
  title={Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin.},
  author={Neale D Ridgway},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1484 2-3},
  pages={129-41}
}
There is ample evidence from experimental models and human metabolic disorders indicating that cholesterol and sphingomyelin (SM) levels are coordinately regulated. Generally it has been observed that altering the cellular content of sphingomyelin or cholesterol results in corresponding changes in mass and/or synthesis of the other lipid. In the case of cholesterol synthesis and trafficking, SM regulates the capacity of membranes to absorb cholesterol and thereby controls sterol flux between… CONTINUE READING