Interactions between metabolism and circadian clocks: reciprocal disturbances

@article{Delezie2011InteractionsBM,
  title={Interactions between metabolism and circadian clocks: reciprocal disturbances},
  author={Julien Delezie and Etienne Challet},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1243}
}
Obesity is a medical condition of excess body fat, recognized as a global epidemic. Besides genetic factors, overconsumption of high‐energy food and a sedentary lifestyle are major obesogenic causes. A newly identified determinant is altered circadian rhythmicity. To anticipate and adapt to daily changes in the environment, organisms have developed an endogenous circadian timing system, comprising a main circadian clock, located in the suprachiasmatic nucleus (SCN) of the hypothalamus… 
[Circadian clocks and energy metabolism in rodents].
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    Advances in experimental medicine and biology
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The understanding of molecular clock control of glucose homeostasis is reviewed, the influence of circadian disruption on glucose metabolism in critical peripheral tissues is detailed, and the contribution of melatonin signalling to the aetiology of type 2 diabetes is explored.
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A number of alterations in circadian entrainment, including jet lag, social jet lag (i.e., desynchronization between body rhythms and normal time schedules), shift work, and exposure to nocturnal light are reviewed, both in human subjects and in laboratory animals.
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High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.
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Cry deficiency results in an increased vulnerability to high-fat diet-induced obesity that might be mediated by increased insulin secretion and lipid storage in adipose tissues, as well as upregulated expression of lipogenic genes, many of which are insulin targets.
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This chapter reviews recent findings that demonstrate the interplay between metabolism and circadian rhythmicity, as well as the repercussions involved in the physiopathology of obesity and cancer.
Metabolic disturbances: role of the circadian timing system and sleep
TLDR
This review tried to summarize the role of the circadian timing system and sleep on energy and metabolic homeostasis and explain the molecular and endocrine mechanisms behind circadian misalignment and sleep disorders that lead to metabolic disorders.
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