Interactions between metabolism and circadian clocks: reciprocal disturbances

@article{Delezie2011InteractionsBM,
  title={Interactions between metabolism and circadian clocks: reciprocal disturbances},
  author={Julien Delezie and Etienne Challet},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1243}
}
Obesity is a medical condition of excess body fat, recognized as a global epidemic. Besides genetic factors, overconsumption of high‐energy food and a sedentary lifestyle are major obesogenic causes. A newly identified determinant is altered circadian rhythmicity. To anticipate and adapt to daily changes in the environment, organisms have developed an endogenous circadian timing system, comprising a main circadian clock, located in the suprachiasmatic nucleus (SCN) of the hypothalamus… 
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[Circadian clocks and energy metabolism in rodents].
TLDR
The metabolic impact of circadian desynchronization justifies the development of preventive or therapeutic strategies that could rely, among others, on dietary interventions combining timed meals and specific composition.
Circadian Rhythms in Diet-Induced Obesity.
  • A. Engin
  • Biology
    Advances in experimental medicine and biology
  • 2017
TLDR
Changing the time of feeding alone can greatly affect body weight and shift work is associated with increased risk for obesity, diabetes and cardio-vascular diseases as a result of unusual eating time and disruption of circadian rhythm.
Chronomedicine and type 2 diabetes: shining some light on melatonin
TLDR
The understanding of molecular clock control of glucose homeostasis is reviewed, the influence of circadian disruption on glucose metabolism in critical peripheral tissues is detailed, and the contribution of melatonin signalling to the aetiology of type 2 diabetes is explored.
Effects of Circadian Disruption on Physiology and Pathology: From Bench to Clinic (and Back)
TLDR
A number of alterations in circadian entrainment, including jet lag, social jet lag (i.e., desynchronization between body rhythms and normal time schedules), shift work, and exposure to nocturnal light are reviewed, both in human subjects and in laboratory animals.
Maternal Adaptation to Pregnancy: Altered Circadian Rhythms of Clock Genes in the Hypothalamus and Metabolic Tissues
TLDR
The reduction of daily oscillations in glucose metabolism ensure a sustained supply of glucose to meet high fetal demands and the central circadian clock undergoes marked adaptations throughout pregnancy, changes that likely contribute to maternal physiological adaptations.
High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.
TLDR
Cry deficiency results in an increased vulnerability to high-fat diet-induced obesity that might be mediated by increased insulin secretion and lipid storage in adipose tissues, as well as upregulated expression of lipogenic genes, many of which are insulin targets.
Physiopathology of Circadian Rhythms: Understanding the Biochemical Mechanisms of Obesity and Cancer
TLDR
This chapter reviews recent findings that demonstrate the interplay between metabolism and circadian rhythmicity, as well as the repercussions involved in the physiopathology of obesity and cancer.
Aging signaling pathways and circadian clock-dependent metabolic derangements
The emerging roles of lipids in circadian control.
Metabolic disturbances: role of the circadian timing system and sleep
TLDR
This review tried to summarize the role of the circadian timing system and sleep on energy and metabolic homeostasis and explain the molecular and endocrine mechanisms behind circadian misalignment and sleep disorders that lead to metabolic disorders.
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